PRAS40 (proline-rich Akt substrate of 40 kDa) is a protein with a prolin-rich domain and appears at about 40 kDa by SDS-PAGE. Initially it was identified as a substrate of PKB/Akt, it was later shown that it is also phosphorylated by mTORC1 (a complex including scaffold protein which is necessary for mTOR and phosphorylation of substrate by mTOR). PRAS40 binds to raptor through the mediation of TOS-motif in its structure in the same way as p70 S6 kinase and 4E-P1 do as substrates of mTOR , then PRAS40 is phosphorylated by mTORC1 at Ser-183 (human), and the phosphorylated PRAS40 will be dissociated from raptor. Therefore, it is considered that PRAS40 is involved in signal-transducing pathway through the mediation of not only PKB/Akt but also mTOR.
AKT1S1; AKT1 substrate 1 (proline-rich); Lobe; PRAS40; proline-rich AKT1 substrate 1; 40 kDa proline-rich AKT substrate; proline-rich Akt substrate, 40 kDa; OTTHUMP00000196757; OTTHUMP00000196758; OTTHUMP00000196759; MGC2865; OTTHUMP00000196760; OTTHUMP00000196756; proline-rich Akt substrate of 40 kDa; proline rich Akt substrate; 40 kDa