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aifm1

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Official Full Name
apoptosis-inducing factor, mitochondrion-associated, 1
Background
Apoptosis-inducing factor (Aif) is a ubiquitously expressed ~57 kDa mitochondrial flavoprotein (67-70 kDa primary transcript) that is capable of inducing chromatin condensation following an apoptotic stimulus. Synthesized in the cytoplasm, Aif is translocated to the intermembrane space of the mitochondria where it is normally found in non-apoptotic cells. Following an apoptotic signal, Aif is released to the cytoplasm from where it is translocated to the nucleus. Once in the nucleus, Aif is capable of inducing nuclear chromatin condensation and large scale DNA fragmentation. Redistribution of the Aif protein can be blocked by bcl-2.
Synonyms
AIFM1; apoptosis-inducing factor, mitochondrion-associated, 1; PDCD8, programmed cell death 8 (apoptosis inducing factor); apoptosis-inducing factor 1, mitochondrial; AIF; striatal apoptosis-inducing factor; programmed cell death 8 (apoptosis-inducing factor); PDCD8; COXPD6; MGC111425; apoptosis-inducing factor, mitochondrion-associated 1; zgc:91994

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