This gene is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (EH) domains and plays a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. The 3 UTR of this gene contains an insulin receptor substrate 3-like pseudogene.
AGFG2; ArfGAP with FG repeats 2; HIV 1 Rev binding protein like , HRBL; arf-GAP domain and FG repeats-containing protein 2; RABR; AGFG2_HUMAN; Arf GAP domain and FG repeats containing protein 2; HIV-1 Rev-binding protein-like protein; HIV1 Rev binding protein like protein; HRBL; Nucleoporin; RAB-R; Rev/Rex activation domain-binding protein related; OTTHUMP00000209085; Rev/Rex activation domain binding protein-related; arf-GAP domain and FG repeat-containing protein 2