This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size;from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of;cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle;formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related;protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant;ratio of approximately 1:15 in the dynactin complex.
ACTR1B; ARP1 actin-related protein 1 homolog B, centractin beta (yeast); ARP1 (actin related protein 1, yeast) homolog B (centractin beta) , CTRN2; beta-centractin; Actin related protein 1B; Actin-related protein 1B; ACTR 1B; ACTY_HUMAN; ARP 1B; ARP1 actin related protein 1 homolog B; ARP1 actin related protein 1 homolog B centractin beta (yeast); ARP1 actin related protein 1 homolog B centractin beta; ARP1 actin related protein 1 yeast homolog B centractin beta; ARP1 yeast homolog B; ARP1B; Beta centractin; Centractin beta (Yeast); Centractin beta; CTRN 2; CTRN2; PC 3; PC3; ARP1B, CTRN2, PC3, ACTR1B