Official Full Name
aminocarboxymuconate semialdehyde decarboxylase
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 22.214.171.124) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.
ACMSD; aminocarboxymuconate semialdehyde decarboxylase; 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; 2 amino 3 carboxymuconate 6 semialdehyde decarboxylase; Picolinate carboxylase; OTTHUMP00000162500; OTTHUMP00000162501; zgc:162888; 2-amino-3-carboxylmuconate-6-semialdehyde decarboxylase