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abi3

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Official Full Name
ABI family, member 3
Background
This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Synonyms
ABI3; ABI family, member 3; NESH; SSH3BP3; ABI gene family member 3; new molecule including SH3; ABI gene family, member 3

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