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abce1

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Official Full Name
ATP-binding cassette, sub-family E (OABP), member 1
Background
ATP binding cassette E1 (ABCE1, also RNase L inhibitor) is an ATPase found in humans involved in viral assembly. It is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily. ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) and inhibits the interferon-regulated 2-5A/RNase L pathway, which is used by viruses. ABCE1 heterodimerize with ribonuclease L and prevents its interaction with 2-5A, antagonizing the anti-viral properties of ribonuclease L, and allow the virus to synthesize viral proteins. It has also been implicated to have an effect in tumor cell proliferation and antiapoptosis.
Synonyms
RLI; OABP; ABC38; RNS4I; RNASEL1; RNASELI; ATP-binding cassette, sub-family E (OABP), member 1; ABCE1; RLI, OABP, ABC38, RNS4I, RNASEL1, RNASELI; ATP-binding cassette sub-family E member 1; RNase L inhibitor; zgc:56045; wu:fb34c09; wu:fe47b01; wu:fi09g07; zgc:111906

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