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abcc9

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Official Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Background
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extra-pancreatic ATP-sensitive potassium channels. Mutations in this gene are associated with cardiomyopathy dilated type 1O. Alternative splicing results in multiple transcript variants.
Synonyms
ABCC9; ATP-binding cassette, sub-family C (CFTR/MRP), member 9; SUR2; ABC37; CANTU; CMD1O; ATFB12; si:dkey-183c2.3; ATP-binding cassette sub-family C member 9; sulfonylurea receptor subunit 2; SUR2A