The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene.
ABCC11; ATP-binding cassette, sub-family C (CFTR/MRP), member 11; ATP-binding cassette sub-family C member 11; MRP8; ABCC 11; ATP binding cassette protein C11; ATP binding cassette sub family C (CFTR/MRP) member 11; ATP binding cassette sub family C member 11; ATP binding cassette transporter MRP8; ATP binding cassette transporter sub family C member 11; EWWD; Multi resistance protein 8; Multidrug resistance associated protein 8; OTTHUMP00000164191; WW; OTTHUMP00000164192; multi-resistance protein 8; ATP-binding cassette protein C11; ATP-binding cassette transporter MRP8; multidrug resistance-associated protein 8; ATP-binding cassette transporter; ATP-binding cassette transporter sub-family C member 11