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Creative Biogene has collected many scientific papers and patents related to part of our core products. Here is a long list of those citing our featured products in stock or partially supplied by our high-quality services. Below are some selected articles to give you an idea of how we assist life science research in academia.

For your convenience when browsing, we have grouped these articles into the following categories:

First Category: Transfected Stable Cell Lines / Stable Cell Line Generation                    

Stable cell lines with specific gene over-expression, knock-down or Knock-out are very helpful in gene function analysis, target discovery, target validation, assay development, and compound screening. Stable cell line is the best solution, not only to produce recombinant protein and antibody, but also for application in drug screenings, gene functional studies etc.

Park, EunJu, et al. "Discovery of novel pyrimidine and malonamide derivatives as TGR5 agonists." Bioorganic & medicinal chemistry letters 24.17 (2014): 4271-4275.
◆ Human TGR5 stable cell line, HEK293 -TGR5

Uz, Metin, Surya K. Mallapragada, and Sacide Alsoy Altinkaya. "Responsive pentablock copolymers for siRNA delivery." RSC Advances 5.54 (2015): 43515-43527.
◆ luciferase-expressing SKOV3 cells

Second Category: cDNA Clones

Creative Biogene provides the largest number of cDNA clones in multiple sets of vector systems with various features, including more than two hundred thousand cDNA clones, in the form of full length cDNA clones or ORF clones.

Hong, Sungkook, et al. "Dominant-negative kinase domain mutations in FGFR1 can explain the clinical severity of Hartsfield syndrome." Human molecular genetics 25.10 (2016): 1912-1922.
◆ human FGF8 (NM_033164.3) and FGFR1 (NM_023110.2) full-length cDNA clones

Third Category: miRNA Clones / miRNA Service

Creative Biogene has supplied multiple 3’UTR target clones and developed an advanced vector-based miRNA expression plasmids , which can help to ease the difficulty in your research.

Yang, Chun, and Yong Pan. "Fluorouracil induces autophagy-related gastric carcinoma cell death through Beclin-1 upregulation by miR-30 suppression." Tumor Biology (2015): 1-6.
◆ Beclin-1 3'-UTR reporter plasmid (pRL-Beclin-1)

Xu, Fulin, et al. "Growth of glioblastoma is inhibited by miR-133-mediated EGFR suppression." Tumor Biology 36.12 (2015): 9553-9558.
◆ EGFR 3'-UTR reporter plasmid (pRL-EGFR)

Zhang, Xiao-Tao, et al. "Impairment of growth of gastric carcinoma by miR-133-mediated Her-2 inhibition." Tumor Biology 36.11 (2015): 8925-8930.
◆ Her-2 3'-UTR reporter plasmid (pRL-Her-2)

Chen, Bing, et al. "MiRNA-494 inhibits metastasis of cervical cancer through Pttg1." Tumor Biology 36.9 (2015): 7143-7149.
◆ Pttg1 miRNA 3'-UTR clone

Liu, Feng, et al. "VEGF-activated miR-144 regulates autophagic survival of prostate cancer cells against Cisplatin." Tumor Biology (2015): 1-7.
◆ Beclin-1 3'-UTR reporter plasmid (pRL-Beclin-1)

Shi, Yan, et al. "miR-203 suppression in gastric carcinoma promotes Slug-mediated cancer metastasis." Tumor Biology (2015): 1-6.
◆ Slug miRNA 3'-UTR clone

Tian, Y. Y., et al. "Restoration of microRNA-373 suppresses growth of human T-cell lymphoma cells by repressing CCND1." European review for medical and pharmacological sciences 20.21 (2016): 4435-4444.
◆ CCND1 3'-UTR reporter plasmid (pRL-CCND1)
CCND1 3'-UTR reporter plasmid with a mutant at the miR-373 binding site (pRL-CCND1-mut)

Su, Lin, et al. "Skp2 regulates non-small cell lung cancer cell growth by Meg3 and miR-3163." Tumor Biology 37.3 (2016): 3925-3931.
◆ Skp2 3'-UTR reporter plasmid (pRL-Skp2)

Chen, Kan, and Wenjun Shi. "Autophagy regulates resistance of non-small cell lung cancer cells to paclitaxel." Tumor Biology 37.8 (2016): 10539-10544.
◆ Beclin-1 3'-UTR reporter plasmid (pRL-Beclin-1) 

Xiao, Wenjun, et al. "Norcantharidin induces autophagy-related prostate cancer cell death through Beclin-1 upregulation by miR-129-5p suppression." Tumor Biology (2015): 1-6.
◆ Beclin-1 3'-UTR re- porter plasmid (pRL-Beclin-1 3′ -UTR)
Beclin-1 3'-UTR reporter plasmid with a mutant at the miR-129-5p binding site (pRL-Beclin-1
3′ -UTR mut)

Chen, Zhi, et al. "Colorectal cancer cells are resistant to anti-EGFR monoclonal antibody through adapted autophagy." American journal of translational research 8.2 (2016): 1190.
◆ Beclin-1 3'-UTR reporter plasmid (pRL-Beclin-1)

Zhang, Zhenxing, et al. "MicroRNA-137 inhibits growth of glioblastoma through EGFR suppression." American journal of translational research 9.3 (2017): 1492.
◆ EGFR 3'-UTR reporter plasmid (pRL-EGFR)

Li, Wei, et al. "miR-132 upregulation promotes gastric cancer cell growth through suppression of FoxO1 translation." Tumor Biology (2015): 1-7.
◆ FoxO1 3'-UTR reporter plasmid (pRL-FoxO1)

Sun, Jiwei, et al. "MiR-200 suppresses metastases of colorectal cancer through ZEB1." Tumor
Biology (2015): 1-7.
◆ ZEB1 mRNA 3'-UTR clone

Bi, Z. M., et al. "Human umbilical cord mesenchymal stem cells ameliorate experimental cirrhosis through activation of keratinocyte growth factor by suppressing microRNA-199." European review for medical and pharmacological sciences 20.23 (2016): 4905.
◆ KGF 3'-UTR reporter plasmid (pRL-KGF)
KGF 3'-UTR reporter plasmid with a mutant at miR-199 binding site (pRL-KGF-mut)

Yu, Zhongxiang, et al. "Overexpression of miR-506 inhibits growth of osteosarcoma through Snail2." American journal of translational research 7.12 (2015): 2716.
◆ Snail2 miRNA 3'-UTR clone

Chen, Lei, Lei Xu, and Gang Wang. "Regulation of MET-mediated proliferation of thyroid carcinoma cells by miR-449b." Tumor Biology 36.11 (2015): 8653-8660.
◆ MET 3'-UTR reporter plasmid (pRL-MET)

Wu, Wen-Bo, et al. "MicroRNA-3713 regulates bladder cell invasion via MMP9." Scientific Reports 6 (2016).
◆ MMP9 3'-UTR reporter plasmid (pRL-MMP9)
MMP9 3'-UTR reporter plasmid with a mutant at miR-3713 binding site (pRL-MMP9-mut)

Hu, Jun, Jun-Feng Xu, and Wei-Li Ge. "MiR-497 enhances metastasis of oral squamous cell carcinoma through SMAD7 suppression." American journal of translational research 8.7 (2016): 3023.
◆ SMAD7 3'-UTR reporter plasmid (SMAD7 3'-UTR)
SMAD7 3'-UTR reporter plasmid with a mutant at the miR-497 binding site (SMAD7 3'-UTR mut)

Yang, Nian-Qin, et al. "Crosstalk between Meg3 and miR-1297 regulates growth of testicular germ cell tumor through PTEN/PI3K/AKT pathway." American journal of translational research 8.2 (2016): 1091.
◆ PTEN 3'-UTR reporter plasmid and mutate

Liu, Wei, et al. "MiR-429 regulates gastric cancer cell invasiveness through ZEB proteins." Tumor Biology (2015): 1-7.
◆ ZEB1 or ZEB2 miRNA 3'-UTR clone

Cui, Z., and Y. Hu. "MicroRNA-124 suppresses Slug-mediated lung cancer metastasis." European review for medical and pharmacological sciences 20.18 (2016): 3802-3811.
◆ Slug 3'-UTR reporter plasmid (pRL-Slug)
Slug 3'-UTR reporter plasmid with a mutant at the miR-124 binding site (pRL-Slug-mut)

Gao, Feng, et al. "Regulation of activating protein-4-associated metastases of non-small cell lung cancer cells by miR-144." Tumor Biology (2015): 1-7.
◆ AP4 miRNA 3'-UTR clone

Chen, Li, et al. "Expression of antisense of microRNA-26a-5p in mesenchymal stem cells increases their therapeutic effects against cirrhosis." American journal of translational research 9.3 (2017): 1500.
◆ HGF 3'-UTR reporter plasmid (pRL-HGF)
HGF 3'-UTR reporter plasmid with a mutant at miR-26a-5p binding site (pRL-HGF-mut)

Sun, Jiping, et al. "Protection of tubular epithelial cells during renal injury via post-transcriptional control of BMP7." Molecular and Cellular Biochemistry (2017): 1-8.
◆ BMP7 3'-UTR and BMP7 3'-UTR with a site mutation at miR-384-5p binding site (BMP7 3'-UTR mut)

Ratovitski, Edward A. "Phospho‐ΔNp63α‐responsive microRNAs contribute to the regulation of necroptosis in squamous cell carcinoma upon cisplatin exposure." FEBS letters 589.12 (2015): 1352-1358.
◆ 3'-UTR reporter plasmid for CYLD (MiUTR1H-02603)

Li, Lin, et al. "Pituitary tumor-transforming gene 1 enhances metastases of cervical cancer cells through miR-3666-regulated ZEB1." Tumor Biology (2015): 1-7.
◆ target sequence for ZEB1 mRNA 3'-UTR clone

Zhang, Zhenxing, et al. "MiR-429 induces apoptosis of glioblastoma cell through Bcl-2." Tumor Biology (2015): 1-7.
◆ Plasmids for Bcl-2 miRNA 3'-UTR clone
Bcl-2 miRNA 3'-UTR with a site mutation at the miR-429-binding site

Fan, Yue, et al. "MicroRNA-454 regulates stromal cell derived factor-1 in the control of the growth of pancreatic ductal adenocarcinoma." Scientific reports 6 (2016).

◆ SDF-1 3'-UTR reporter plasmid (SDF-1 3'-UTR)
SDF-1 3'-UTR reporter plasmid with a mutant at the miR-454 binding site (SDF-1 3'-UTR mut)

Wu, Xiaoli, et al. "Role of Beclin-1-Mediated Autophagy in the Survival of Pediatric Leukemia Cells." Cellular Physiology and Biochemistry 39.5 (2016): 1827-1836.
◆ Beclin-1 3'-UTR reporter plasmid (Beclin-1 3'-UTR)
Beclin-1 3'-UTR reporter plasmid with a mutant at the miR-93 binding site (Beclin-1 3'-UTR mut)

Forth Category: Vectors / Plasmid DNA Production Service

Creative Biogene offers a wide range of vectors including expression vectors and clone vectors, as well as phagemid vectors and viral vectors.

Mandal, Papita, et al. "Unexpected histone H3 tail-clipping activity of glutamate dehydrogenase." Journal of Biological Chemistry 288.26 (2013): 18743-18757.
◆ Mouse GLUD1 ORF clone (with N-His tag)
Bacterial expression vector pReceiver-B01

Khalili, Ehsan, et al. "Production of Recombinant Human scFv Against Tetanus Toxin HeavyChain by Phage Display Technology." Monoclonal antibodies in immunodiagnosis and immunotherapy 34.5 (2015): 303-309.
pComb3xss vector

Zare, Hamed, et al. "Production of nanobodies against prostate-specific membrane antigen (PSMA) recognizing LnCaP cells." Int J Biol Markers 29.2 (2014): e169-79.
pComb3x phage display vector

Ricci, Ada, et al. "Visualizing the relevance of bacterial blue‐and red‐light receptors during plant–pathogen interaction." Environmental microbiology reports 7.5 (2015): 795-802.
◆ pBSL15 vector

Fifth Category: shRNA Clones / Custom Viral Service

Creative Biogene supplies a series of shRNAs, which could make tight hairpins used for silencing target gene expression via RNA interference. Besides, our state-of-the-art facilities and highly experienced staff are available in order to assist in all areas of virus vector design and construction, as well as the generation of the virus in a quick turnaround.

Kiessling, Silke, et al. "Enhancing circadian clock function in cancer cells inhibits tumor growth." BMC biology 15.1 (2017): 13.
◆ Bmal1 shRNA
Scrambled shRNA Lentiviral Particles

Sixth Category: cDNA Synthesis Kit

Li, B., et al. "IKVAV regulates ERK1/2 and Akt signalling pathways in BMMSC population growth and proliferation." Cell proliferation 47.2 (2014): 133-145.
◆ Revert Aid First Strand cDNA Synthesis Kit

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