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Magea1

Official Full Name
Homo sapiens melanoma antigen family A, 1 (directs expression of antigen MZ2-E) DNA.
Background
Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). An important group of antigens is coded by the MAGE family of genes. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues.
Synonyms
MAGEA1; melanoma antigen family A, 1 (directs expression of antigen MZ2-E); MAGE1; melanoma-associated antigen 1; cancer/testis antigen family 1; member 1; CT1.1; melanoma antigen family A 1; melanoma antigen MAGE 1; melanoma associated antigen 1; melanoma associated antigen MZ2 E; MGC9326; antigen MZ2-E; MAGE-1 antigen; melanoma antigen MAGE-1; cancer/testis antigen 1.1; melanoma-associated antigen MZ2-E; cancer/testis antigen family 1, member 1; CT1.1, MAGE1

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