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DROSHA


Official Full Name
drosha ribonuclease III
Organism
Homo sapiens
Gene ID
29102
Background
This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016]
Synonyms
RN3; ETOHI2; RNASEN; RANSE3L; RNASE3L; HSA242976

Cat.No. Product Name Price
SHH220614 shRNA set against Human RNASEN(NM_013235.4) Inquiry
SHH281097 shRNA set against Human DROSHA (NM_013235.4) Inquiry
SHH281101 shRNA set against Mouse DROSHA (NM_026799.3) Inquiry
SHH396428 shRNA set against Rat RNASEN (NM_001107655.2) Inquiry
SHW000464 shRNA set against Chicken DROSHA (NM_001006379) Inquiry
SHW012078 shRNA set against Danio rerio RNASEN (NM_001110472) Inquiry
Cat.No. Product Name Price
CDCH385960 Human DROSHA ORF clone(NM_013235.4) Inquiry
CDCR057372 Human DROSHA ORF clone (NM_001100412.1) Inquiry
CDFH005426 Human DROSHA cDNA Clone(NM_001100412.1) Inquiry
MiUTR1H-08864 DROSHA miRNA 3'UTR clone Inquiry
MiUTR3H-10252 DROSHA miRNA 3'UTR clone Inquiry
SKO1005 DROSHA Validated sgRNA vector Inquiry
CDCB161939 Chicken DROSHA ORF Clone (NM_001006379) Inquiry
CDCB173553 Danio rerio RNASEN ORF Clone (NM_001110472) Inquiry
CDCB188261 Rabbit DROSHA ORF clone (XM_008262093.1) Inquiry
CDCR057378 Mouse Rnasen ORF clone (NM_001130149.1) Inquiry
CDCR259296 Mouse Drosha ORF Clone(NM_026799.3) Inquiry
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