Tel: 1-631-626-9181 (USA)   44-208-144-6005 (Europe)


Official Full Name
TGF-beta activated kinase 1/MAP3K7 binding protein 3
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
TAB3; TGF-beta activated kinase 1/MAP3K7 binding protein 3; MAP3K7IP3, mitogen activated protein kinase kinase kinase 7 interacting protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TAK1 binding protein 3; TAB-3; TAK1-binding protein 3; NAP1; MAP3K7IP3; map3k7ip3l; si:dkey-30h22.6; si:ch211-232d19.8; mitogen-activated protein kinase kinase kinase 7 inter

Interested in learning more?

Contact us today for a free consultation with the scientific team and discover how Creative Biogene can be a valuable resource and partner for your organization.

Request a quote today!