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STEAP2

Official Full Name
STEAP family member 2, metalloreductase
Background
This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Synonyms
STEAP2; STEAP family member 2, metalloreductase; PCANAP1, prostate cancer associated protein 1 , six transmembrane epithelial antigen of the prostate 2; metalloreductase STEAP2; IPCA 1; STAMP1; STMP; prostate cancer associated protein 1; prostate cancer

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