Official Full Name

secreted phosphoprotein 1

Background

The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Synonyms

SPP1; secreted phosphoprotein 1; OPN; BNSP; BSPI; ETA-1; osteopontin; uropontin; nephropontin; SPP1/CALPHA1 fusion; urinary stone protein; early T-lymphocyte activation 1; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1); BNSP, bone sialoprotein I , OPN, osteopontin; early T lymphocyte activation 1; ETA 1; osteopontin-C; osteopontin-D; bone sialoprotein 1; MGC110940; OP; Bsp; Eta; Ric; Opnl; Apl-1; Spp-1; AA960535; AI790405; minopontin; zgc:111821; spp1 protein