This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein secreted by the exocrine pancreas that is highly similar to the REG1A protein. The related REG1A protein is associated with islet cell regeneration and diabetogenesis, and may be involved in pancreatic lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication.
REG1B; regenerating islet-derived 1 beta; regenerating islet derived 1 beta (pancreatic stone protein, pancreatic thread protein); lithostathine-1-beta; lithostathine 1 beta; PSPS2; REGH; REGI BETA; REGL; secretory pancreatic stone protein 2; Lithostathine 1 beta precursor; Regenerating islet derived 1 beta (pancreatic stone protein pancreatic thread protein); Regenerating islet derived 1 beta; Regenerating protein I beta; PSP-2; REG-1-beta; pancreatic stone protein 2; regenerating islet-derived protein 1-beta; regenerating islet-derived 1 beta (pancreatic stone protein, pancreatic thread protein); REGI-BETA