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PROC

Official Full Name
protein C, inactivator of coagulation factors Va and VIIIa
Organism
Homo sapiens
GeneID
5624
Background
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]
Synonyms
PC; APC; PROC1; THPH3; THPH4;

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