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PRICKLE1

Official Full Name
prickle homolog 1 (Drosophila)
Background
This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3.
Synonyms
PRICKLE1; prickle homolog 1 (Drosophila); prickle like 1 (Drosophila); prickle-like protein 1; EPM1B; FLJ31937; FLJ31627; MGC138902; MGC138903; Prickle 1; Prickle like protein 1; Prickle-like 1; REST-Interacting LIM Domain Protein; REST/NRSF interacting LIM domain protein 1; RILP; REST/NRSF-interacting LIM domain protein 1; REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein; RILP, EPM1B

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