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PKD1


Official Full Name
polycystin 1, transient receptor potential channel interacting
Organism
Homo sapiens
Gene ID
5310
Background
This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described. [provided by RefSeq, Oct 2008]
Synonyms
PBP; PC1; Pc-1; TRPP1; eliosin

Cat.No. Product Name Price
SHH376348 shRNA set against Mouse PKD1 (NM_013630.2) Inquiry
Cat.No. Product Name Price
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CDCG002047 Mouse PKD1 ORF clone(NM_013630.2) Inquiry
CDCG002050 Rat PKD1 ORF clone(NM_001257352.1) Inquiry
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