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NPPB


Official Full Name
natriuretic peptide B
Organism
Homo sapiens
Gene ID
4879
Background
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020]
Synonyms
BNP; Iso-ANP

Cat.No. Product Name Price
SHG103069 shRNA set against Rat Nppb(NM_031545.1) Inquiry
SHG103033 shRNA set against Human NPPB(NM_002521.2) Inquiry
SHG103051 shRNA set against Mouse Nppb(NM_008726.4) Inquiry
SHH354368 shRNA set against Human NPPB (NM_002521.2) Inquiry
SHH354372 shRNA set against Mouse NPPB (NM_008726.4) Inquiry
SHH354376 shRNA set against Rat NPPB (NM_031545.1) Inquiry
SHW005429 shRNA set against Chicken NPPB (NM_204925) Inquiry
Cat.No. Product Name Price
CDCS410827 Human NPPB ORF Clone (BC025785) Inquiry
CDFR012703 Rat Nppb cDNA Clone(NM_031545.1) Inquiry
MiUTR1H-06879 NPPB miRNA 3'UTR clone Inquiry
MiUTR1M-07781 NPPB miRNA 3'UTR clone Inquiry
MiUTR1R-04257 NPPB miRNA 3'UTR clone Inquiry
CDCB159608 Human NPPB ORF clone (BC025785) Inquiry
CDCB166904 Chicken NPPB ORF Clone (NM_204925) Inquiry
CDCB181256 Rabbit NPPB ORF clone (XM_008275383.1) Inquiry
CDCR246014 Mouse Nppb ORF Clone(NM_008726.4) Inquiry
CDCR379736 Rat Nppb ORF Clone(NM_031545.1) Inquiry
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