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MAGEA5

Official Full Name
melanoma antigen family A, 5
Background
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This MAGEA gene encodes a protein that is C-terminally truncated compared to other family members, and this gene can be alternatively interpreted to be a pseudogene. The protein is represented in this Gene record in accordance with the assumed protein-coding status defined in the literature. Read-through transcription exists between this gene and the upstream melanoma antigen family A, 10 (MAGEA10) gene.
Synonyms
MAGEA5; melanoma antigen family A, 5; MAGE5; melanoma-associated antigen 5; cancer/testis antigen family 1; member 5; CT1.5; MAGE 5a antigen; MAGE 5b antigen; MGC129526; Cancer/testis antigen 1.5; Cancer/testis antigen family 1 member 5; MAGE 5 antigen; MAGEA4; Melanoma antigen family A 5; Melanoma associated antigen 5; MAGE-5 antigen; MAGE-5a antigen; MAGE-5b antigen; cancer/testis antigen family 1, member 5

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