|CSC-DC007903||Panoply™ Human KATNB1 Knockdown Stable Cell Line||Inquriy|
|CSC-SC007903||Panoply™ Human KATNB1 Over-expressing Stable Cell Line||Inquriy|
|CDCB162690||Chicken KATNB1 ORF Clone (NM_001030559)||Inquriy|
|CDCB179619||Danio rerio KATNB1 ORF Clone (NM_213018)||Inquriy|
|CDCB189638||Rabbit KATNB1 ORF clone (XM_002711544.2)||Inquriy|
|CDCR261415||Mouse Katnb1 ORF Clone(NM_028805.2)||Inquriy|
|CDCR291532||Human KATNB1 ORF Clone(NM_005886.2)||Inquriy|
|CDCR370691||Rat Katnb1 ORF Clone(NM_001024746.1)||Inquriy|
|CDCS412471||Human KATNB1 ORF Clone (BC001353)||Inquriy|
|CDFH009574||Human KATNB1 cDNA Clone(NM_005886.2)||Inquriy|
|CDFR003650||Rat Katnb1 cDNA Clone(NM_001024746.1)||Inquriy|
|MiUTR1H-05086||KATNB1 miRNA 3'UTR clone||Inquriy|
|MiUTR1M-06195||KATNB1 miRNA 3'UTR clone||Inquriy|
|MiUTR1R-02766||KATNB1 miRNA 3'UTR clone||Inquriy|
|SHH322499||shRNA set against Human KATNB1 (NM_005886.2)||Inquriy|
|SHH322503||shRNA set against Mouse KATNB1 (NM_028805.2)||Inquriy|
|SHH322507||shRNA set against Rat KATNB1 (NM_001024746.1)||Inquriy|
|SHL187632||shRNA set against Human KATNB1(NM_005886.2)||Inquriy|
|SHL187650||shRNA set against Rat Katnb1(NM_001024746.1)||Inquriy|
|SHL187686||shRNA set against Mouse Katnb1(NM_028805.2)||Inquriy|
|SHW001215||shRNA set against Chicken KATNB1 (NM_001030559)||Inquriy|
|SHW018144||shRNA set against Danio rerio KATNB1 (NM_213018)||Inquriy|
The microtubule-severing protein complex katanin is composed two subunits, the ATPase subunit, p60/KATNA1, and the noncatalytic regulatory subunit, p80/KATNB1. In developing neurons, Katanin localizes to microtubules and centrosomes and is essential for microtubule shortening and release.KATNA1 is a member of the AAA (ATPases Associated with diverse cellular Activities) domain containing protein family, whereasKATNB1 binds to p60 and targets it to subcellular structures including the centrosome, further mediating its interactions with Dynein, LIS1, and NDEL1. It is reported that KATNB1 is linked to infertility, regulation of centriole and cilia formation in ﬁsh and mammals, as well as neocortical brain development. KATNB1 is ubiquitously expressed during embryonic development, including germ cells in humans and mouse, mitotic/meiotic spindles and cilia. Furthermore, null and hypomorphic KATNB1 gene mutations show a novel correlation between KATNB1 dysregulation and the development of impaired left–right signaling, including cardiac malformations.
Some reports have shown that loss of KATNB1 orthologs in zebrafish and flies results in microcephaly, recapitulating the human phenotype. In the developing Drosophila optic lobe, KATNB1 loss specifically affects the asymmetrically dividing neuroblasts, which display supernumerary centrosomes and spindle abnormalities during mitosis, leading to cell cycle progression delays and reduced cell numbers. Furthermore, KATNB1depletion results in dendritic arborization defects in sensory and motor neurons, affecting neural architecture. And a missense mutation in the highly conserved WD40 domain of KATNB1 has been shown to cause azoospermia and male sterility in mice.
It has been found that deleterious mutations in KATNB1 that result in a spectrum of cerebral cortical development (MCD) disorders, including microcephaly co-occurring with lissencephaly or less severe neuronal migration abnormalities such as periventricular or subcortical heterotopias. In addition, recent research has shown that KATNB1 plays a role in human spermatogenesis and the genetic variants in KATNB1 are associated with oligoasthenoteratozoospermia (OAT) in humans. KATNB1 was present during spermatid development, and in particular localized to the microtubules of the manchette, a structure required for sperm head shaping.
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