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ITM2B


Official Full Name
integral membrane protein 2B
Organism
Homo sapiens
Gene ID
9445
Background
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]
Synonyms
BRI; FBD; ABRI; BRI2; E25B; E3-16; RDGCA; imBRI2; BRICD2B

Cat.No. Product Name Price
SHH321589 shRNA set against Human ITM2B (NM_021999.4) Inquiry
SHH321593 shRNA set against Mouse ITM2B (NM_008410.2) Inquiry
SHH321597 shRNA set against Rat ITM2B (NM_001006963.1) Inquiry
SHL184386 shRNA set against Rat Itm2b(NM_001006963.1) Inquiry
SHL184404 shRNA set against Mouse Itm2b(NM_008410.2) Inquiry
SHW005585 shRNA set against Chicken ITM2B (NM_205085) Inquiry
SHW015933 shRNA set against Danio rerio ITM2BA (NM_199646) Inquiry
Cat.No. Product Name Price
CDCB159437 Human ITM2B ORF clone (BC000554) Inquiry
CDFG022277 Mouse Itm2b cDNA Clone(BC004731) Inquiry
CDFR001541 Rat Itm2b cDNA Clone(NM_001006963.1) Inquiry
MiUTR1M-06161 ITM2B miRNA 3'UTR clone Inquiry
MiUTR1R-02719 ITM2B miRNA 3'UTR clone Inquiry
MiUTR3H-06370 ITM2B miRNA 3'UTR clone Inquiry
CDCB167060 Chicken ITM2B ORF Clone (NM_205085) Inquiry
CDCB177408 Danio rerio ITM2BA ORF Clone (NM_199646) Inquiry
CDCB183618 Rabbit ITM2B ORF clone (XM_002720722.1) Inquiry
CDCR245443 Mouse Itm2b ORF Clone(NM_008410.2) Inquiry
CDCR368602 Rat Itm2b ORF Clone(NM_001006963.1) Inquiry
CDCS415407 Human ITM2B ORF Clone (BC000554) Inquiry
CDCS415408 Human ITM2B ORF Clone (BC016148) Inquiry
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