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ISCU


Official Full Name
iron-sulfur cluster assembly enzyme
Organism
Homo sapiens
Gene ID
23479
Background
This gene encodes a component of the iron-sulfur (Fe-S) cluster scaffold. Fe-S clusters are cofactors that play a role in the function of a diverse set of enzymes, including those that regulate metabolism, iron homeostasis, and oxidative stress response. Alternative splicing results in transcript variants encoding different protein isoforms that localize either to the cytosol or to the mitochondrion. Mutations in this gene have been found in patients with hereditary myopathy with lactic acidosis. A disease-associated mutation in an intron may activate a cryptic splice site, resulting in the production of a splice variant encoding a putatively non-functional protein. A pseudogene of this gene is present on chromosome 1. [provided by RefSeq, Feb 2016]
Synonyms
HML; ISU2; NIFU; NIFUN; hnifU; 2310020H20Rik

Cat.No. Product Name Price
SHH320893 shRNA set against Human ISCU (NM_014301.3) Inquiry
SHH320897 shRNA set against Mouse ISCU (NM_025526.4) Inquiry
SHH320901 shRNA set against Rat ISCU (NM_001105936.1) Inquiry
Cat.No. Product Name Price
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CDCH387325 Mouse ISCU ORF clone(NM_025526.4) Inquiry
CDCL121717 Mouse ISCU ORF clone (NM_213595.2) Inquiry
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CDCS413564 Human ISCU ORF Clone (BC011906) Inquiry
CDCS413565 Human ISCU ORF Clone (BC061903) Inquiry
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