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HRK

Official Full Name
harakiri, BCL2 interacting protein
Background
Activator of apoptosis Hrk regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK. HRK interacts with BCL2 and BCLXL via the BH3 domain, but not with the death-promoting BCL2-related proteins BAX, BAK, or BCLXS. HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL
Synonyms
HRK; DP5; HARAKIRI; harakiri, BCL2 interacting protein (contains only BH3 domain); activator of apoptosis hara-kiri; activator of apoptosis Hrk; Neuronal death protein DP5; BCL2-interacting protein; BH3-interacting domain-containing protein 3; death protein 5; harakiri, BCL2-interacting protein (contains only BH3 domain); BID3

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