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GNAS


Official Full Name
GNAS complex locus
Organism
Homo sapiens
Gene ID
2778
Background
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]
Synonyms
AHO; GSA; GSP; POH; GPSA; NESP; SCG6; SgVI; GNAS1; PITA3; AIMAH1; C20orf45

Cat.No. Product Name Price
SHH091595 shRNA set against Rat Gnas(NM_019132.1) Inquiry
SHH091613 shRNA set against Mouse Gnas(NM_201616.1) Inquiry
SHH091685 shRNA set against Mouse Gnas(NM_019690.2) Inquiry
SHH304690 shRNA set against Mouse GNAS (NM_010309.3) Inquiry
SHR030736 shRNA set against Mouse Gnas(NM_001077507.1) Inquiry
SHH091557 shRNA set against Human GNAS(NM_000516.4) Inquiry
SHH091577 shRNA set against Mouse Gnas(NM_022000.2) Inquiry
SHH091667 shRNA set against Human GNAS(NM_001077490.1) Inquiry
SHH091703 shRNA set against Mouse Gnas(NM_010309.3) Inquiry
SHH091721 shRNA set against Human GNAS(NM_080426.2) Inquiry
SHH091751 shRNA set against Human GNAS(NM_016592.2) Inquiry
SHH091769 shRNA set against Mouse Gnas(NM_201618.1) Inquiry
SHH091787 shRNA set against Human GNAS(NM_080426.2) Inquiry
SHH304686 shRNA set against Human GNAS (NM_080425.2) Inquiry
SHH304694 shRNA set against Rat GNAS (NM_019132.1) Inquiry
SHR030918 shRNA set against Mouse Gnas(NM_201617.1) Inquiry
Cat.No. Product Name Price
CDFH007718 Human GNAS cDNA Clone(NM_001077490.1) Inquiry
CDFL005140 Mouse Gnas cDNA Clone(NM_022000.2) Inquiry
CDFL005141 Mouse Gnas cDNA Clone(NM_201616.1) Inquiry
CDFL005142 Mouse Gnas cDNA Clone(NM_201617.1) Inquiry
CDFR003698 Rat Gnas cDNA Clone(NM_001024823.4) Inquiry
CDFR011430 Rat Gnas cDNA Clone(NM_019132.1) Inquiry
CDFR011825 Rat Gnas cDNA Clone(NM_021845.5) Inquiry
MiUTR1H-04104 GNAS miRNA 3'UTR clone Inquiry
MiUTR1H-04105 GNAS miRNA 3'UTR clone Inquiry
MiUTR1M-05195 GNAS miRNA 3'UTR clone Inquiry
MiUTR1M-05196 GNAS miRNA 3'UTR clone Inquiry
MiUTR1M-05197 GNAS miRNA 3'UTR clone Inquiry
MiUTR1M-05198 GNAS miRNA 3'UTR clone Inquiry
MiUTR1M-05199 GNAS miRNA 3'UTR clone Inquiry
MiUTR1R-02170 GNAS miRNA 3'UTR clone Inquiry
MiUTR3H-00979 GNAS miRNA 3'UTR clone Inquiry
MiUTR3H-00980 GNAS miRNA 3'UTR clone Inquiry
MiUTR3H-00981 GNAS miRNA 3'UTR clone Inquiry
CDFL005139 Mouse Gnas cDNA Clone(NM_010309.3) Inquiry
MiUTR3H-00982 GNAS miRNA 3'UTR clone Inquiry
MiUTR3H-00985 GNAS miRNA 3'UTR clone Inquiry
CDFG005767 Human GNAS cDNA Clone(NM_080425.2) Inquiry
CDCS405715 Human GNAS ORF Clone (BC002722) Inquiry
CDCR277051 Mouse Gnas ORF Clone(NM_201616.1) Inquiry
CDFG018555 Mouse Gnas cDNA Clone(NM_001077507.1) Inquiry
CDCB195575 Rabbit GNAS ORF clone (XM_008248815.1) Inquiry
CDCL113069 Mouse Gnas ORF clone (NM_019690.2) Inquiry
CDCL113073 Mouse Gnas ORF clone (NM_001077507.1) Inquiry
CDCL113075 Mouse Gnas ORF clone (NM_201618.1) Inquiry
CDCL113077 Mouse Gnas ORF clone (NM_201617.1) Inquiry
CDCL113079 Mouse Gnas ORF clone (NM_010309.3) Inquiry
CDCL113081 Mouse GNAS ORF clone (NM_080426.2) Inquiry
CDCL113085 Mouse GNAS ORF clone (NM_001077490.1) Inquiry
CDCR233950 Mouse Gnas ORF Clone(NM_001077510.2) Inquiry
CDCR370460 Rat Gnas ORF Clone(NM_001024823.4) Inquiry
CDCR378473 Rat Gnas ORF Clone(NM_019132.1) Inquiry
CDCR378839 Rat Gnas ORF Clone(NM_021845.5) Inquiry
CDCR383065 Mouse Gnas ORF Clone(NM_022000.2) Inquiry
CDCS405716 Human GNAS ORF Clone (BC008855) Inquiry
CDCL113083 Mouse GNAS ORF clone (NM_080425.2) Inquiry
CDCB160273 Human GNAS ORF clone (NM_000516) Inquiry
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