Official Full Name

CTP synthase 2

Background

The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene.

Synonyms

CTPS2; CTP synthase II; CTP synthase 2; CTP synthetase 2; CYTIDINE 5 PRIME TRIPHOSPHATE SYNTHETASE 2; FLJ43358; MGC32997; PYRG2_HUMAN; UTP--ammonia ligase 2; UTP-ammonia ligase; CTP synthetase type 2; CTP synthetase isoform; cytidine 5-triphosphate synthetase 2; DKFZp686C17207