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C14orf169

Official Full Name
chromosome 14 open reading frame 169
Background
NO66 is a lysine-specific demethylase that removes methyl groups from histone H3 at lysine 4 and and lysine 36. This enzyme has been shown to more readily demethylate trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 Lys4 (H3K4me1) consistent with its role in modulating the histone code. This protein is a highly conserved, constitutive nucleolar component that shows a dual localization pattern with strong enrichment in the granular part of nucleoli and in distinct nucleoplasmic entities.
Synonyms
C14ORF169; chromosome 14 open reading frame 169; lysine-specific demethylase NO66; FLJ21802; NO66; hsNO66; nucleolar protein 66; MYC-associated protein with JmjC domain; MAPJD

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