|CSC-DC001327||Panoply™ Human BARX2 Knockdown Stable Cell Line||Inquiry|
|CSC-SC001327||Panoply™ Human BARX2 Over-expressing Stable Cell Line||Inquiry|
|CDCB166876||Chicken BARX2 ORF Clone (NM_204896)||Inquiry|
|CDCB185138||Rabbit BARX2 ORF clone (XM_008259259.1)||Inquiry|
|CDCR033202||Mouse Barx2 ORF clone (NM_013800.2)||Inquiry|
|CDCS411397||Human BARX2 ORF Clone (BC111432)||Inquiry|
|MiUTR1H-00808||BARX2 miRNA 3'UTR clone||Inquiry|
|MiUTR1M-01975||BARX2 miRNA 3'UTR clone||Inquiry|
|SHG034309||shRNA set against Mouse Barx2(NM_013800.2)||Inquiry|
|SHG034327||shRNA set against Human BARX2(NM_003658.4)||Inquiry|
|SHH244922||shRNA set against Human BARX2 (NM_003658.4)||Inquiry|
|SHH244929||shRNA set against Mouse BARX2 (NM_013800.2)||Inquiry|
|SHW005401||shRNA set against Chicken BARX2 (NM_204896)||Inquiry|
BARX2 is a member of the Bar class homeobox gene family, which also includes BarHI and BarH2 from Drosophila. The BARX2 gene is located on human chromosome 11q25; it has four exons ranging in size from 85 to 1099 bp, and is associated with the congenital disease Jacobson syndrome. BARX2 has 87% amino acid identity with BARX1 and they are all expressed in multiple epithelial tissues. Regarding the function of BARX2, it has been shown to play a key role in regulating cellular processes involved in cell adhesion and cytoskeletal remodeling in myoblast fusion, and is a key process for carcinogenesis and metastasis.
BARX2 and OSCC
Oral squamous cell carcinoma (OSCC) is one of the most common cancers in the world. Abnormalities in miRNA regulation are known to play an important role in the pathogenesis of OSCC. Further studies have found that miR-187 increases the carcinogenicity of OSCC cells, especially migration. The BARX2 gene has been identified as a target for miR-187. BARX2 expression inhibited migration, invasion, anchorage-independent colony formation and orthotopic tumorigenesis of OSCC cells. MiR-187-induced migration phenotype and neck metastasis were rescued by BARX2 expression. BARX2 expression was down-regulated in most OSCCs, and this down-regulation was particularly pronounced in tumors with advanced lymph node metastasis. In addition, plasma miR-187 was significantly higher in OSCC patients than in normal subjects. In conclusion, miR-187-BARX2 plays an important role in driving the progression of OSCC carcinogenesis.
BARX2 and CRC
Colorectal cancer (CRC) is a malignant tumor originating from the colorectal mucosal epithelium and is one of the most common malignant tumors in the clinic. It is reported that low expression of BARX2 was significantly associated with tumor node metastasis (TNM) staging, AJCC staging, differentiation and relapse in patients with CRC. Patients with lower BARX2 expression levels had reduced disease-free survival and overall survival. Furthermore, a trend toward shorter overall survival in the group of patients with BARX2-negative tumors independent of advanced AJCC stage and poor differentiation was determined by Kaplan-Meier survival analysis. Based on univariate and multivariate analysis, BARX2 expression was an independent prognostic factor for determining CRC prognosis. In conclusion, low BARX2 expression was associated with progression of CRC and could serve as a potential independent prognostic biomarker for CRC patients.
BARX2 and NSCLC
Epithelial-mesenchymal transition (EMT) has important functions in cancer. Recently, microRNAs have been reported to be involved in EMT by modulating target genes. Some studies have shown that miR-942 was relatively highly expressed in human non-small-cell lung cancer (NSCLC) tissues and cells. In vitro experiments have demonstrated that overexpression of miR-942 promoted cell migration, invasion and angiogenesis. Related experiments indicated that miR-942 contributed to NSCLC metastasis in vivo, and that BARX2 was predicted to be a downstream target of miR-942. Overexpression of BARX2 reverses the functional changes caused by miR-942. In addition, miR-942 increased EMT-related proteins N-cadherin and vimentin by inhibiting BARX2, while E-cadherin expression was reduced. In conclusion, miR-942 induces EMT-related metastasis by directly targeting BARX2, which may provide a potential therapeutic strategy for NSCLC.
BARX2 and GC
Recently, some studies have found that the expression level of BARX2 in human gastric cancer (GC) tissues was lower than that in adjacent normal mucosa. In multivariate analysis, BARX2 expression emerged as an independent prognostic factor for disease-free and overall survival. Kaplan-Meier survival analysis showed a trend toward even shorter overall survival in the group of patients with BARX2-negative tumors. Using in vitro and in vivo assays, Mi et al. has demonstrated that under normal conditions, BARX2 inhibited GC cell proliferation and invasion by inhibiting the Wnt/β-catenin signaling pathway. These findings suggest that the reduction or loss of BARX2 inhibits proliferation and invasion of GC cells, and that the reduction of BARX2 could serve as an independent prognostic biomarker for poor prognosis in patients with GC.
BARX2 and HCC
Hepatocellular carcinoma (HCC) is a malignant tumor with an increasing incidence, making it the most common cancer in the world. Some studies have shown that BARX2 expression was lower in HCC tissues compared to matching adjacent non-cancerous tissues. The low expression level of BARX2 was significantly associated with tumor size, tumor differentiation, clinical stage, metastasis and recurrence. In addition, patients with low expression of BARX2 survived poorly. Importantly, multivariate Cox regression analysis showed that low BARX2 expression was an independent marker for lower overall survival. Furthermore, a significant negative correlation was observed between the expression of BARX2 and the EMT marker. These results provide evidence that low expression levels of BARX2 in HCC are significantly associated with tumor metastasis, and that BARX2 may be an independent prognostic biomarker for HCC patients.
In conclusion, BARX2 plays an important role in controlling the expression of cell adhesion molecules and has been reported to be associated with an increasing number of tumor types. Therefore, further study of the function of BARX2 and its important role in the mechanism of tumorigenesis is of great significance and value for the diagnosis and treatment of cancer.
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