B3GAT1

Official Full Name

beta-1,3-glucuronyltransferase 1

Organism

Homo sapiens

Gene ID

27087

Background

The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Synonyms

NK1; CD57; HNK1; LEU7; NK-1; GLCATP; GLCUATP

Cat.No.	Product Name	Price
CSC-DC001263	Panoply™ Human B3GAT1 Knockdown Stable Cell Line	Inquiry
CSC-SC001263	Panoply™ Human B3GAT1 Over-expressing Stable Cell Line	Inquiry

Cat.No.	Product Name	Price
AD01652Z	Human B3GAT1 adenoviral particles	Inquiry
LV05973L	human B3GAT1 (NM_054025) lentivirus particles	Inquiry

Cat.No.	Product Name	Price
SHG088651	shRNA set against Rat B3gat1(NM_054003.1)	Inquiry
SHG088703	shRNA set against Human B3GAT1(NM_018644.3)	Inquiry
SHG088721	shRNA set against Mouse B3gat1(NM_029792.1)	Inquiry
SHH244194	shRNA set against Human B3GAT1 (NM_018644.3)	Inquiry
SHH244198	shRNA set against Mouse B3GAT1 (NM_029792.1)	Inquiry
SHH244202	shRNA set against Rat B3GAT1 (NM_054003.1)	Inquiry
SHW004134	shRNA set against Chicken B3GAT1 (NM_001277839)	Inquiry

Cat.No.	Product Name	Price
CDCG001287	Human B3GAT1 ORF clone(NM_018644.3)	Inquiry
CDFG007206	Human B3GAT1 cDNA Clone(NM_054025.2)	Inquiry
CDFR013705	Rat B3gat1 cDNA Clone(NM_054003.1)	Inquiry
MiUTR1H-00766	B3GAT1 miRNA 3'UTR clone	Inquiry
MiUTR1M-01934	B3GAT1 miRNA 3'UTR clone	Inquiry
MiUTR1R-00494	B3GAT1 miRNA 3'UTR clone	Inquiry
CDCB165609	Chicken B3GAT1 ORF Clone (NM_001277839)	Inquiry
CDCB190655	Rabbit B3GAT1 ORF clone (XM_008248350.1)	Inquiry
CDCL182792	Mouse B3gat1 ORF clone(NM_029792.1)	Inquiry
CDCL182793	Rat B3GAT1 ORF clone(NM_054003.1)	Inquiry
CDCR314478	Human B3GAT1 ORF Clone(NM_054025.2)	Inquiry

Detailed Information

Beta-1, 3-glucuronyltransferase 1 (B3GAT1) is an enzyme encoded by the B3GAT1 gene, whose enzymatic activity creates the CD57 epitope on other cell surface proteins.

B3GAT1 encodes a member of the glucuronyl-transferase gene family that functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (Human Natural Killer-1, also known as CD57 and LEU7). The B3GAT1 gene and antigen CD57 play an important role in the immune system and tumor processes. CD57 is a marker of well-differentiated cells with high cytotoxic potential. In addition, regardless of the underlying disease, CD57 is a hallmark of immune system dysfunction. Changes in the glycosylation of plasma proteins caused by the B3GAT1 polymorphisms may be a predisposing or prognostic factor in numerous diseases.

Recent Researches

Mastocytosis is a relatively uncommon disease that is classified as a myeloproliferative neoplasm. However, its symptoms are placing patients at the crossroads of dermatology, hematology, and allergology. Furthermore, there are significant differences in B3GAT1 gene expression in patients with IVA compared to patients without previous insect sting anaphylaxis.

When plasmodium falciparum replicates in infected red blood cells, the latter becomes more easily to be cleared through the spleen. Parasites express adhesion proteins on the surface of infected erythrocytes to avoid host clearance, which effectively anchor these cells to specific receptors in the host vasculature. In the placenta, VAR2CSA (Var gene subfamily, required for malaria parasite infection) binds to a distinct type of chondroitin sulfate (CS) glycosaminoglycan (GAG) chain called CSA. This is the key event underlying placental malaria pathogenesis. Within the CS maturation pathway, CHST11 mediates CSA-specific 4-O-sulfation of the GalNAc residues of the CS chain. B3GAT1 is required for the synthesis of the basal GlcA-Gal-Gal-Xyl-Ser linker tetrasaccharide common to all GAGs. RNAi-mediated knock down of B3GAT1, CSGALNACT1, and CHST11 expression inhibite the binding of VAR2 to U2OS cells.

B3GAT1 is the key enzyme in the biosynthesis of the carbohydrate epitope HNK-1, which is present on a number of cell adhesion molecules important in neurodevelopment. B3GAT1 close to the telomeres may also have an important impact on the genetic susceptibility to schizophrenia.

References:

Salanti A, et al. Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein. Cancer cell. 2015; 28(4):500-514.
Clausen TM, et al. Oncofetal Chondroitin Sulfate Glycosaminoglycans are Key Players in Integrin Signaling and Tumor Cell Motility. Molecular cancer research. 2016; 14(12):1288-1299.
Górska A, et al. The Role of TRAF4 and B3GAT1 Gene Expression in the Food Hypersensitivity and Insect Venom Allergy in Mastocytosis. Archivum Immunologiaeet. Therapiae Experimentalis. 2016; 64(6):497-503.
Nishitha M. Reddy, Management of Patients with Histologic Transformation. Clinical Lymphoma Myeloma and Leukemia. 2017.

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B3GAT1

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