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AUH


Official Full Name
AU RNA binding methylglutaconyl-CoA hydratase
Organism
Homo sapiens
Gene ID
549
Background
This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities. The encoded protein is a methylglutaconyl-CoA hydratase that catalyzes the hydration of 3-methylglutaconyl-CoA to 3-hydroxy-3-methyl-glutaryl-CoA, a critical step in the leucine degradation pathway. This protein also binds AU-rich elements (AREs) found in the 3' UTRs of rapidly decaying mRNAs including c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. This protein is localizes to the mitochondrial matrix and the inner mitochondrial membrane and may be involved in mitochondrial protein synthesis. Mutations in this gene are the cause of 3-methylglutaconic aciduria, type I. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Synonyms
ECRG4; C2orf40

Cat.No. Product Name Price
SHG086033 shRNA set against Human AUH(NM_001698.2) Inquiry
SHG086307 shRNA set against Mouse Auh(NM_016709.2) Inquiry
SHH243698 shRNA set against Human AUH (NM_001698.2) Inquiry
SHH243702 shRNA set against Mouse AUH (NM_016709.2) Inquiry
SHH243706 shRNA set against Rat AUH (NM_001108407.1) Inquiry
SHW002020 shRNA set against Chicken AUH (NM_001031429) Inquiry
SHW003518 shRNA set against Chicken AUH (NM_001252606) Inquiry
SHW006891 shRNA set against Danio rerio AUH (NM_001003576) Inquiry
Cat.No. Product Name Price
CDFR008026 Rat Auh cDNA Clone(NM_001108407.1) Inquiry
MiUTR1H-00744 AUH miRNA 3'UTR clone Inquiry
MiUTR1M-01866 AUH miRNA 3'UTR clone Inquiry
CDCB163495 Chicken AUH ORF Clone (NM_001031429) Inquiry
CDCB164993 Chicken AUH ORF Clone (NM_001252606) Inquiry
CDCB168366 Danio rerio AUH ORF Clone (NM_001003576) Inquiry
CDCR252940 Mouse Auh ORF Clone(NM_016709.2) Inquiry
CDCR375067 Rat Auh ORF Clone(NM_001108407.1) Inquiry
CDCS410386 Human AUH ORF Clone (BC020722) Inquiry
Cat.No. Product Name Price
CC-186 AUH Easy KO Kit Inquiry
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