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Aph1b

Official Full Name
APH1B gamma secretase subunit
Background
This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein.
Synonyms
APH1B; anterior pharynx defective 1 homolog B (C. elegans); gamma-secretase subunit APH-1B; APH 1B; DKFZp564D0372; PSFL; Anterior pharynx defective 1 homolog B; Anterior pharynx defective 1B like; Anterior pharynx defective 1b short splicing variant; Aph 1beta; APH-1b; Aph-1beta; Aph1 beta; APH1B_HUMAN; Aph1beta; Gamma secretase subunit APH 1B; Gamma secretase subunit APH1B; Gamma secretase sununit; Presenilin stabilisation factor like; Presenilin-stabilization factor-like; PRO 1328; PRO1328; TAAV 688; TAAV688; FLJ33115; APH1B gamma secretase subunit; APH1A; wu:fc41h05; wu:fi53a04; anterior pharynx defective 1B; anterior-pharynx-defective protein 1b

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