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APH1B

Official Full Name
aph-1 homolog B, gamma-secretase subunit
Organism
Homo sapiens
GeneID
83464
Background
This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011]
Synonyms
PSFL; APH-1B; PRO1328; TAAV688; aph-1beta;

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