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Apex2

Official Full Name
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
Background
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5 to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER).
Synonyms
APEX2; APEX nuclease (apurinic/apyrimidinic endonuclease) 2; DNA-(apurinic or apyrimidinic site) lyase 2; APE2; APEXL2; XTH2; APEX nuclease 2; AP endonuclease 2; AP endonuclease XTH2; APEX nuclease-like 2; apurinic-apyrimidinic endonuclease 2; DNA-apurini; DNA-apurinic or apyrimidinic site lyase 2; apurinic/apyrimidinic endonuclease-like 2; zgc:55889

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