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APEX2


Official Full Name
apurinic/apyrimidinic endodeoxyribonuclease 2
Organism
Homo sapiens
Gene ID
27301
Background
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Synonyms
APE2; XTH2; ZGRF2; APEXL2

Cat.No. Product Name Price
SHG064441 shRNA set against Human APEX2(NM_014481.2) Inquiry
SHG064523 shRNA set against Mouse Apex2(NM_029943.1) Inquiry
SHH238186 shRNA set against Human APEX2 (NM_014481.2) Inquiry
SHH238190 shRNA set against Mouse APEX2 (NM_029943.1) Inquiry
SHW016380 shRNA set against Danio rerio APEX2 (NM_200146) Inquiry
Cat.No. Product Name Price
CDCR028754 Human APEX2 ORF clone (NM_014481.2) Inquiry
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MiUTR1H-00464 APEX2 miRNA 3'UTR clone Inquiry
MiUTR1M-01568 APEX2 miRNA 3'UTR clone Inquiry
SKO1047 APEX2 Validated sgRNA vector Inquiry
CDCB177855 Danio rerio APEX2 ORF Clone (NM_200146) Inquiry
CDCB187532 Rabbit APEX2 ORF clone (XM_008272672.1) Inquiry
CDCR028756 Mouse Apex2 ORF clone (NM_029943.1) Inquiry
CDCS413663 Human APEX2 ORF Clone (BC002959) Inquiry
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