The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described.
ARID4A; AT rich interactive domain 4A (RBP1-like); RBBP1, retinoblastoma binding protein 1; AT-rich interactive domain-containing protein 4A; RBP 1; RBP1; AT rich interactive domain containing protein 4A; ARID 4A; ARID domain containing protein 4A; AT rich interactive domain 4A; RBBP 1; RBBP1; RBP1 like; OTTHUMP00000179023; OTTHUMP00000179024; OTTHUMP00000197517; retinoblastoma binding protein 1; retinoblastoma-binding protein 1; ARID domain-containing protein 4A; RBP-1; RBBP-1; wu:fc43f03; wu:fi06c05; wu:fi11g07; wu:fi14h03; zgc:110391; fc43f03; fi11g07; fi14h03