Official Full Name

angiogenin, ribonuclease, RNase A family, 5

Background

Angiogenin (Ang) also known as ribonuclease 5 is a protein that in humans is encoded by the ANG gene. Angiogenin is a potent stimulator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Hooper et al. (2003) reviewed the evidence that angiogenins are involved in host defense and noted that inflammation provokes upregulated ANG mRNA expression in liver and an increase in detectable ANG protein in serum. Weremowicz et al. (1989, 1990) assigned the human angiogenin gene to chromosome 14q11.

Synonyms

Angiogenin; Ang; ribonuclease 5; ALS9; HEL168; RNASE4; RNASE5; angiogenin, ribonuclease, RNase A family, 5; ribonuclease A; ribonuclease A/angiogenin; leukocyte ribonuclease A-1; RAA1