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AKAP13


Official Full Name
A-kinase anchoring protein 13
Organism
Homo sapiens
Gene ID
11214
Background
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]
Synonyms
BRX; LBC; p47; HA-3; Ht31; c-lbc; PRKA13; AKAP-13; AKAP-Lbc; ARHGEF13; PROTO-LB; PROTO-LBC

Cat.No. Product Name Price
SHH234214 shRNA set against Mouse AKAP13 (NM_029332.1) Inquiry
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Cat.No. Product Name Price
CDCR373039 Rat Akap13 ORF Clone(NM_001106271.2) Inquiry
CDFL001094 Mouse Akap13 cDNA Clone(NM_029332.1) Inquiry
CDFR006027 Rat Akap13 cDNA Clone(NM_001106271.2) Inquiry
CDCB192244 Rabbit AKAP13 ORF clone (XM_008248881.1) Inquiry
CDCR262501 Mouse Akap13 ORF Clone(NM_029332.1) Inquiry
CDCR294574 Human AKAP13 ORF Clone(NM_007200.4) Inquiry
CDCS412885 Human AKAP13 ORF Clone (BC050312) Inquiry
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