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ACOX1

Official Full Name
acyl-CoA oxidase 1, palmitoyl
Background
The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms
ACOX1; acyl-CoA oxidase 1, palmitoyl; acyl Coenzyme A oxidase 1, palmitoyl; peroxisomal acyl-coenzyme A oxidase 1; PALMCOX; ACOX1_HUMAN; AOX; EC 1.3.3.6; Palmitoyl CoA oxidase; Palmitoyl-CoA oxidase; Peroxisomal acyl coenzyme A oxidase 1; SCOX; Straight chain acyl CoA oxidase; Straight-chain acyl-CoA oxidase; acyl-CoA oxidase, straight-chain; peroxisomal fatty acyl-CoA oxidase; acyl-Coenzyme A oxidase 1, palmitoyl; ACOX; MGC1198; zgc:92584; wu:fb59h12; zgc:114033

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