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ABCB8

Official Full Name
ATP-binding cassette, sub-family B (MDR/TAP), member 8
Background
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.ABC proteins transport various molecules across extra- and intra-cellular membranes.ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).This protein is a member of the MDR/TAP subfamily.Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation.The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol.This protein may also play a role in the transport of phospholipids into mitochondrial membranes.
Synonyms
ABCB8; ATP-binding cassette, sub-family B (MDR/TAP), member 8; ATP-binding cassette sub-family B member 8, mitochondrial; EST328128; M ABC1; MABC1; mitochondrial ABC protein; mitochondrial ATP-binding cassette 1; M-ABC1; zgc:113037

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