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Rat Gpbar1-FLAG Stable Cell Line-CHO

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Cat.No.
CSC-RG0180
Background
GPBA is a G-protein coupled receptor, also known as TGR5 or GPR131. Stimulation of the receptor with bile acids or other ligands induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway and internalization of the receptor. Quantitative analyses for TGR5 mRNA have shown that it is abundantly expressed in monocytes/macrophages. The receptor is an attractive therapeutic target for the prevention and treatment of obesity and is highly associated with Type II diabetes and metabolic syndrome. GPBA has been implicated in inflammatory diseases, regulation of homeostasis by bile acids, as well as cardiovascular, neurological, and hepatic diseases.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
Gpbar1
Synonyms
Gpbar1; G protein-coupled bile acid receptor 1; Tgr5; G-protein coupled bile acid receptor 1; M-BAR; G protein-coupled receptor; membrane-type receptor for bile acids
Gene ID
UniProt ID
Q80T02
Chromosome Location
9q33
Pathway
Class A/1 (Rhodopsin-like receptors); GPCR ligand binding; Signal Transduction; Signal by GPCR
Function
G-protein coupled receptor activity

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