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Rat Casr-FLAG Stable Cell Line-HEK293T

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Cat.No.
CSC-RG0424
Background
CASR is a calcium-sensing receptor and plays an important role in regulating PTH secretion. It is expressed in many different tissues, such as parathyroid cells, pituitary cells, kidney, fibroblasts, keratinocytes and human colon epithelial cells. CASR is a potential therapeutic target for the treatment of many diseases, including hyperparathyroidism and osteoporosis. Mutations in the CASR gene can result in gain or loss of receptor function. Familial Hypocalciuric Hypercalcemia (FHH) and Neonatal Severe Primary Hyperparathyroidism (NSHPT) have been associated with loss of CASR function, while Autosomal Dominant Hypocalcemia (ADH) and Bartter syndrome type V have been associated with gain of CASR function.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293T
Ship
Dry ice
Gene Information
Official Symbol
Casr
Synonyms
CASR; calcium-sensing receptor; extracellular calcium-sensing receptor; PCaR1; parathyroid Cell calcium-sensing receptor; Calcium-sensing receptor (hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism); Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism);
Gene ID
Pathway
Class C/3 (Metabotropic glutamate/pheromone receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class C Metabotropic glutamate, pheromone, organism-specific biosystem; Signal Transduction, organism-specific biosystem;
Function
G-protein coupled receptor activity; G-protein coupled receptor activity; protein binding; receptor activity; signal transducer activity;

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