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Reporter Stable Cell Lines


Creative Biogene’s best trained and most experienced experts provide a wide variety of reporter cell lines for applications in functional genomics research and drug discovery.

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Reporter Stable Cell Lines

Reporter Stable Cell Lines

As useful tools for scientific research, reporter stable cell lines are those cells involved in expression of reporter protein(s) which are engineered through integrating the reporter expression cassettes into cell genomes mediated by plasmid or lentivirus vectors. In the studies of life science and biotechnology, the commonly used reporter genes are visually identifiable including green fluorescent protein (GFP), red fluorescent protein (RFP), luciferase, secreted alkaline phosphatase (SEAP) etc.

According to the upstream regulator of the reporter gene, reporter cell lines can be further divided into two groups: 1) Constitutive Reporter Cell Lines in which reporters are constitutively expressed under the control of a constitutive, strong promoter such as CMV promoter; and 2) Inducible Reporter Cell Lines in which reporters are inducibly expressed under the control of a minimal promoter fused to multiple inducer response elements.

Based on years of experience and in-depth investigation, scientists at Creative Biogene have established a large number of stable reporter cells in many popular cell lines suitable for multiple applications.

Constitutive Reporter Cell Lines
- GFP Reporter Cell Lines
- RFP Reporter Cell Lines
- GFP/RFP Reporter Cell Lines
- Luciferase Reporter Cell Lines
- Dual Reporter Cell Lines
Inducible Reporter Cell Lines

Table 1. Frequently Requested - Constitutive Reporter Cell Lines

Category Reporter Host Cell
Fluorescent Reporter GFP 143 B, 324, 4T1, 9L, A375, A498, A549, AGS, Anip 973, ASPC -1, B16F0, B16 F10, Boy, BT 474, BV2, Bx Pc3, Ca761, CAOV3, Capan-1, Capan-2, CHO-K1, CNE2Z, colo205, Colon 38, COS-7, CT-26, DAOY, DU145, EKVX, FaDu, FEMX I, Flo-1, H460, H69, HCC70, HCT-116, HCT-15, HCT-8, HEK293, HEK293T, HeLa, Hep2, Hep 3B, HEP-G2, HGC27, HOP-62, HT 1080, HT-29, HTB 9, Huh-7, JURKAT, K562, KM-12, KM 28 BM, KU-7, LL/2, LnCap, LOXMIVI, LS 174, Ls180, L-SLM, MCF7, MDA-MB-231, MDA-MB-435, MDA-MB-435 2C5, MDA-MB-435 4A4, MDA-MB-453, MDA-MB-468, MDCK, Mel526, MIA-Paca 2, MMT 060562, MOLM13, MSTO-211H, MV3, N87, NALM6, NCI-H1299, NCIH1437, NCI-H1975, NCI-H661, NCI-N87, NIH3T3, NUGC 4, OPM2, OST, OVCAR-3, OVCAR-8, PaCa28, Panc-1, Pan02, PC-3, PC-12, R40LN, RGMI#186, RPMI8226, SH-SY5Y, SK-BR-3, SK-Hep-1, SK-LU-1, Sk-mel-5, SK-OV-3, SL4, SN12C, SNB-19, SOSN2, SW1116, SW480, SW620, SCC-25, T24T, T47D, TOV21, U2OS, U87 MG, U937, UACC257, UM-UC-3, UM-UC 14, Vcap, WiDr, XPAI
RFP 143 B, 4T1, A375, A549, ASPC-1, B16F0, B16-F10, Bx Pc3, BV2, CEM, CHO-K1, CNE2Z, Colon 38, Colo26, CT26.WT, Dunning3327, DAOY, FEMX I, FaDu, FG A-12, H9C2(2-1), HCT-116, HCT-8, HEK293, HEK293T, Hep2, Hep 3B, Hep G2, HGC27, HMMG/HOS, HT 1080, HT29, Huh-7, KAK-1, LnCap, LOXMIVI, LL/2 H460, MDA-MB-231, MDA-MB-435 4A4, MDA-MB-435 2C5, MDA-MB-468, Mel526, MGC803, MIA-Paca 2, MMT 060562, MSTO-211H, MV3, MX-1, NCI-H1299, NCIH1568, NCIH1975, NIH3T3, NPA, NUGC 4, OVCAR-3, OVCAR-5, OVCAR-8, OST, Pan02, PC-3, R40LN, R90L, R90P, SK-BR-3, SW1116, SW480, SL4, SN12C, SOSN2, SH-SY5Y, SK-Hep-1, Sk-mel-5, T24T, T47D, TOV21, U14, U2OS, U87 MG, UM-UC 14, XPAI
GFP + RFP 143 B, B16 F10, DU145, H460, HCT-116, HT 1080, Lewis Lung, MDA-MB-435, MDA-MB-231, MIA-Paca 2, MMT 060562, MV3, PC3, U87 MG, XPAI
Luciferase Reporter Luciferase 4T1, A375, A549, B16F10, CT26.WT, HCT116, HT1080, LL/2, MCF-7, MDA-MB-231, SKOV-3
Dual Reporter GFP + Luciferase AGS, HCC70, HT-29, MCF7, NCI-H1299, NCI-H1975, NCI-H661, NCI-N87
RFP + Luciferase A549, CNE2Z, GBC-SD, H9C2(2-1), HCT-8, HEK293T, Hep3B, HepG2, HOS, Huh7, Li-7, MDA-MB-231, NCI-H1299, PLC/PRF/5, RBE, SK-HEP-1

Table 2. Frequently Requested - Inducible Reporter Cell Lines

Category Reporter Co-expression Factor Host Cell
ATF6 Pathway Luciferase -- CHO
AP1 Pathway Luciferase -- HEK293T, HeLa
Androgen Receptor(AR) Pathway Luciferase -- MDA-MB-453
BMP Pathway Luciferase -- HEK293
CHOP Pathway Luciferase -- CHO
CREB Pathway Luciferase -- CHO, HEK293, NIH3T3
ELK1 Pathway Luciferase -- HeLa, HEK293
Estrogen Receptor(ER) Pathway Luciferase -- T47D
HIF Pathway Luciferase -- Cos-7, HeLa, Neuro2a, NIH3T3
GFP -- Ca761, MCF7, MDA-MB-231
IFN-α Pathway Luciferase -- HeLa
IL6 Pathway Luciferase -- HEK293
IRF Pathway Luciferase -- HEK293, HepG2
NFAT Pathway Luciferase -- HeLa, Jurkat T, K562, NIH3T3
NF-kB Pathway SEAP TLR2, TLR3, TLR4, TLR7, TLR8, TLR9, TLR10, TLR13, mTLR11, mTLR12 HEK293
SEAP -- HEK293, RAW264.7
Luciferase -- A549, C2C12, HeLa, HEK293, HepG2, Jurkat T, MCF-7, MDA-MB-231, MEF, Neuro2a, NIH3T3
NRF2 Pathway Luciferase -- HEK293, HepG2, MCF7, NIH3T3
p53 Pathway Luciferase -- HeLa, RKO
SMAD Pathway Luciferase -- HepG2, NIH3T3
SRF Pathway Luciferase -- HeLa
STAT Pathway Luciferase -- HeLa
Wnt Pathway Luciferase -- CHO, HEK293, HEK293T, HeLa

Applications

  1. Analysis of gene expression and regulation
  2. In vivo and in vitro imaging studies
  3. Evaluation the development of tumor or cancer
  4. Monitoring the activation of intracellular signaling pathways induced by microbial molecules or cytokines
  5. Studying the interactions among receptors, ligands and agonists
  6. Functional genomics research and drug discovery

Features

  1. Creative Biogene provides a large choice of reporter cell lines.
  2. All reporter cell lines provided by Creative Biogene are guaranteed free of mycoplasma contamination.
  3. If you could not find a reporter cell line of interest, our scientists can also tailor a reporter cell line based on your request.