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Mouse Ccr9-FLAG Stable Cell Line-HEK293T Gqi5

Cat.No.
CSC-RG0214
Abbr
HEK293T Gqi5-MouseCcr9-FLAG
Alias
CCR9,CCR-9,CC-CKR-9,Cmkbr10,GPR-9-6
Growth Properties
Adherent
Host Cell
HEK293T Gqi5
Morphology
Epithelial
Shipping
Dry ice
Species
Mouse
Background
CCR9 (C-C chemokine receptor type 9) is a thymus-specific receptor for chemokine CCL25 (SCYA25 or TECK). It is an alternative co-receptor with CD4 for HIV-1 infection. Activation of the receptor may lead to potent cFLIP(L)-independent resistance to cycloheximide-induced apoptosis and modest resistance to Fas-mediated apoptosis possibly via activation of multiple signaling components involving Akt and glycogen synthase kinase 3beta. Thus, dissection of signaling components involved in the CCR9-mediated antiapoptosis could be a framework for cell survival mechanisms and may provide options for therapeutic interventions.

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