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Human UTS2R/Galpha16 Stable Cell Line-Chem-2

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Cat.No.
CSC-RG0766
Background
Urotensin II, a cyclic 11-13 residue peptide expressed in motoneurons of the spinal cord, acts as a potent vasoconstrictor. The effects of urotensin II are mediated by binding to a GPCR, GPR14, which is expressed in endothelium, smooth muscle, heart and pancreas. Genetic deletion of GPR14 in mice renders aortae refractile to the contractile activity of urotensin II without changing baseline hemodynamics. Pharmacological inhibition of urotensin II/GPR14 interactions prevents renal insufficiency following renal artery ligation. Thus, GPR14 is an attractive target for a number of cardiovascular diseases.
Growth Properties
Adherent
Host Cell
Chem-2
Ship
Dry ice
Gene Information
Official Symbol
UTS2R
Synonyms
UTS2R; urotensin 2 receptor; G protein coupled receptor 14 , GPR14; urotensin-2 receptor; UR-II-R; urotensin II receptor; G protein-coupled receptor 14; G-protein coupled receptor 14; UTR; UTR2; GPR14; UR-2-R;
Gene ID
MIM
UniProt ID
Q9UKP6
Chromosome Location
17q25.3
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Other, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem;
Function
G-protein coupled receptor activity; receptor activity; signal transducer activity; urotensin II receptor activity;

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