Creative biogene
SHARE THIS
facebook twitterlinkedingoogle plusStumbleUpon blog


Human TSHR/Apoaequorin Stable Cell Line-CHO

See other products for TSHR
Cat.No.
CSC-RG1284
Background
The glycoprotein hormone receptor family consists of the luteinizing hormone receptor, the follicle-stimulating hormone receptor, and the thyroid stimulating hormone (TSH) receptor. TSH, which is released from the pituitary gland, binds to the TSH receptor on thyroid cells to control size and function of the thyroid gland. The TSH receptor signals through Gs to elevate intracellular cAMP in the thyroid gland, which regulates iodide uptake, and transcription of thyroglobulin (Tg), thyroid peroxidase (TPO), and sodium-iodide symporter. The TSH receptor also signals Gq and phospholipase C to regulate iodide efflux, H2O2 production, and thyroglobulin iodination. Autoimmunity to the TSH receptor causes hyperthyroidism (Graves disease) or hypothyroidism (Hashimoto thyroiditis) when the autoantibodies function as agonists or antagonists, respectively, at the TSH receptor.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
TSHR
Synonyms
TSHR; thyroid stimulating hormone receptor; thyrotropin receptor; LGR3; TSH-R; thyrotropin receptor-I, hTSHR-I; seven transmembrane helix receptor; thyroid-stimulating hormone receptor; thyroid stimulating hormone receptor, isoform 2; CHNG1; hTSHR-I; MGC75129;
Gene ID
UniProt ID
P16473
Chromosome Location
14q24-q31
Pathway
Arf6 signaling events, organism-specific biosystem; Arf6 trafficking events, organism-specific biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem;
Function
protein binding; receptor activity; signal transducer activity; thyroid-stimulating hormone receptor activity; thyroid-stimulating hormone receptor activity;
Related Products
Cat#
Product Name
Host Cell
Gene Symbol
Species
Price
CSC-DC016715
HEK293 ,Hela, etc.
TSHR
Human
CSC-RG0271
HEK293T
Tshr
Rat
CSC-RG0572
CHO-K1
TSHR
Human
Cat#
Product Name
Titer
Product Size
Species
Price
AD00271Z
1x10^11~1x10^12 PFU/ml
1 x 0.2 ml
Human
AD17007Z
>1x 10^9 vp/ml
1 x 0.2 ml
Human
Cat#
Product Name
Size/Form
Species
Price

Related Services

Quick Inquiry

Please input "biogene" as verification code.

CONTACT CREATIVE BIOGENE

45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828

Terms & Conditions | Privacy Policy | Sitemap | FAQ | © 2010-2018 Creative Biogene. All Rights Reserved.