Creative biogene
SHARE THIS
facebook twitterlinkedingoogle plusStumbleUpon blog


Human TRHR/beta-Arrestin Stable Cell Line-CHO

See other products for TRHR
Cat.No.
CSC-RG1609
Background
The thyroid stimulating hormone receptor (TSHR) is expressed in the membrane of thyroid follicular cells. It is involved in regulating thyrocyte cell growth and function. TSHR is also the target autoantigen in thyroid autoimmune diseases. Autoantibodies to TSHR that act as agonists are responsible for the hyperthyroidism of Graves" Disease. Another class of autoantibodies that block the binding of TSH to TSHR may mediate the hypothyroidism associated with Hashimoto"s thyroiditis, primary myxoedema, and neonatal hypothyroidism. This TSHR cell line contains the cDNA sequence identical to GenBank sequence NM_000369 except for one base pair mutation that results in a change in amino acid at position 727 (from glutamic acid to aspartic acid). This has been reported as a natural variant. The allele with glutamic acid has been proposed as a predisposing factor in toxic multinodular goiter pathogenesis.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
TRHR
Synonyms
TRHR; thyrotropin-releasing hormone receptor; thyroliberin receptor; TRH-R; MGC141920;
Gene ID
UniProt ID
P34981
Chromosome Location
8
Pathway
Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem;
Function
receptor activity; signal transducer activity; thyrotropin-releasing hormone receptor activity;
Related Products
Cat#
Product Name
Host Cell
Gene Symbol
Species
Price
CSC-DC016558
HEK293 ,Hela, etc.
TRHR
Human
Cat#
Product Name
Titer
Product Size
Species
Price
AD16859Z
>1x 10^9 vp/ml
1 x 0.2 ml
Human
Cat#
Product Name
Size/Form
Species
Price

Related Services

Quick Inquiry

Please input "biogene" as verification code.
  Order Info: Human TRHR/beta-Arrestin Stable Cell Line-CHO  order info
TRHR Related Products
Contact us to order
USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828
Email: info@creative-biogene.com
CBpromise

24x7 CUSTOMER SERVICE

CONTACT US TO ORDER

;

CONTACT CREATIVE BIOGENE

45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828

Terms & Conditions | Privacy Policy | Sitemap | FAQ | © 2010-2018 Creative Biogene. All Rights Reserved.