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Human TR alpha(LBD)-GAL4(DBD) Stable Cell Line-HEK 293T(UAS-bla)

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Cat.No.
CSC-RN0034
Background
The thyroid hormone receptors are members of nuclear hormone receptor superfamily. Nuclear hormone receptors function as ligand inducible transcription factors capable of acting as co-repressors and/or co-activators for gene expression. Nuclear receptors contain a series of conserved domains or regions. These domains/regions include a variable NH2-domain (A/B region), a conserved DNAbinding domain (DBD or region C), a linker region (region D), a ligand binding domain (LBD or region E), and in some receptors a variable COOH-terminal (region F). The TR DNA binding domain recognizes and interacts with the thyroid hormone response elements (TREs). TR can bind to this half-site, AGGTCA, as a monomer, a homodimer, or a heterodimer with the RXR. The TR/RXR heterodimer is associated with corepressor proteins at the TRE in the absence of ligand. Upon binding of thyroid hormone, TR undergoes a conformational change, releasing corepressor proteins and allowing for the interaction with coactivator proteins that enhance TRE-driven gene transcription.
Thyroid hormones (TH) have important effects on development, growth, and metabolism. They are encoded by two different genes, alpha and beta. Their effect is mediated principally through T3, which regulates gene expression by binding to the TH receptors (TR)-α and –β. Thyroid hormones affect most mammalian tissues. In excess, these hormones may cause weight loss, tachycardia, atrial arrhythmias, and heart failure. Studies of TR isoform-specific knockout mice and patients with resistance to thyroid hormone syndrome suggest that TR-α mediates the effects of thyroid hormone on heart rate.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK 293T
Ship
Dry ice
Gene Information
Official Symbol
THRA
Synonyms
AR7; CHNG6; EAR7; ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2; c-ERBA-1; EAR-7; ERBA-related 7; V-erbA-related protein 7; c-erbA-alpha; nuclear receptor subfamily 1 group A member 1; thyroid hormone receptor alpha; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid normone nuclear receptor alpha variant 1; triiodothyronine receptor
Gene ID
MIM
UniProt ID
P10827
Chromosome Location
17q11.2
Pathway
Endochondral Ossification; Gene Expression; Generic Transcription Pathway; Neuroactive ligand-receptor interaction; Nuclear Receptors; Nuclear Receptor transcription pathway
Function
TBP-class protein binding; chromatin DNA binding; protein binding; protein complex binding; protein domain specific binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; steroid receptor RNA activator RNA binding; thyroid hormone binding; thyroid hormone receptor activity; transcription factor binding; transcription regulatory region DNA binding; zinc ion binding

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