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Human TBXA2R/Galpha15 Stable Cell Line-Chem-1

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Cat.No.
CSC-RG0746
Background
TP receptors (Thromboxane A2 receptors) are widely distributed among different organ systems and have been localized on both cell membranes and intracellular structures. TP receptors belong to G protein-coupled receptor family. Activation of TP receptors induces platelet aggregation, vascular and respiratory smooth muscle constriction, and enhances mitogenic responses of vascular smooth muscle cells that are stimulated by growth factors. The human TP receptor is encoded by a single gene that is alternatively spliced at the carboxyl terminus, resulting in two isoforms, TPalpha (343 residues) and TPalpha (407 residues). Both isoforms couple to Gq pathway, but couple oppositely to adenylate cyclase.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
TBXA2R
Synonyms
TBXA2R; thromboxane A2 receptor; prostanoid TP receptor; TXA2-R; BDPLT13;
Gene ID
MIM
UniProt ID
P21731
Chromosome Location
19p13.3
Pathway
Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Eicosanoid ligand-binding receptors, organism-specific biosystem; G alpha (12/13) signalling events, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem;
Function
G-protein coupled receptor activity; guanyl-nucleotide exchange factor activity; protein binding; receptor activity; signal transducer activity; thromboxane A2 receptor activity;

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