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Human TACR3/Galpha15 Stable Cell Line-Chem-1

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Cat.No.
CSC-RG0764
Background
NK3 is one of three mammalian G-protein coupled receptors subtypes (NK1, NK2, NK3) that mediate the biological effects of the tachykinin peptide family. Neurokinin B is the tachykinin family peptide with the highest affinity to NK3R, but it still induces a response with NK1 and NK2 with lower potency. NK3, like the other tachykinin receptors, signals through Gq to stimulate intracellular calcium. Mammalian tachykinins are present in the brain and gut. NK3 receptor antagonists reduce intestinal motility and nociception in animal models of gastrointestinal disorders, and may be effective in irritable bowel syndrome.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
TACR3
Synonyms
TACR3; tachykinin receptor 3; neuromedin-K receptor; neurokinin beta receptor; NK3R; NK-3 receptor; neurokinin B receptor; NKR; NK-3R; TAC3RL; MGC148060; MGC148061;
Gene ID
MIM
UniProt ID
P29371
Chromosome Location
4q25
Pathway
Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem;
Function
G-protein coupled receptor activity; receptor activity; signal transducer activity; tachykinin receptor activity;

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