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Human TACR2/Apoaequorin Stable Cell Line-CHO

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Cat.No.
CSC-RG1338
Background
The tachykinin peptide family in mammals comprises three peptides, substance P, neurokinin A and neurokinin B, which bind to the tachykinin receptor family of GPCRs, NK1, NK2 and NK3. Tachykinins have prominent activity in the GI system, in which they stimulate intestinal contraction and salivation; these effects are mediated by NK1 and NK2. Experiments with selective antagonists of NK2, SR 48,968 and MEN 10,376 indicate that NK2 mediates neurokinin-induced constriction of pulmonary artery and bronchus. NK2 antagonists display efficacy in treatment of irritable bowel disorder.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
TACR2
Synonyms
TACR2; tachykinin receptor 2; NKNAR, TAC2R; substance-K receptor; NK2R; SKR; NK-2R; NK-2 receptor; substance K receptor; neurokinin 2 receptor; neurokinin A receptor; seven transmembrane helix receptor; NKNAR; TAC2R;
Gene ID
MIM
UniProt ID
P21452
Chromosome Location
10pter-q23
Pathway
Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem;
Function
G-protein coupled receptor activity; receptor activity; signal transducer activity; tachykinin receptor activity;

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