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Human SUCNR1/Apoaequorin Stable Cell Line-CHO

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Cat.No.
CSC-RG1288
Background
GPR91 is a class A G-protein coupled receptor that binds selectively to succinate, an intermediate in the citric acid cycle, and couples to both the Gi/Go and Gq pathways. Renal proximal tubules are a major site of GPR91 expression, and succinate-mediated activation of renal GPR91 stimulates the release of renin to cause vasoconstriction and hypertension. In addition, GPR91 in retinal neurons mediates retinal vascularization induced by succinate, which accumulates in response to hypoxia. Dendritic cells also highly express GPR91, which mediates succinate-induced immune cell migration and activation in vitro and in vivo. Therefore, suppression of GPR91 is a potential strategy for treatment of vascular retinopathies, hypertension, and inflammation.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
SUCNR1
Synonyms
SUCNR1; succinate receptor 1; G protein coupled receptor 91 , GPR91; P2Y purinoceptor 1; G protein-coupled receptor 91; G-protein coupled receptor 91; GPR91;
Gene ID
MIM
UniProt ID
Q9BXA5
Chromosome Location
3q25.1
Pathway
GPCRs, Class A Rhodopsin-like, organism-specific biosystem;
Function
G-protein coupled purinergic nucleotide receptor activity; G-protein coupled receptor activity; receptor activity; signal transducer activity;

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